FIG. 4.

Proposed weight loss therapy based on theory. Daily omega-3 fatty acid supplements (especially with decreased dietary omega-6 fatty acids) will reduce levels of AEA and 2-AG, reducing stimulation of CB₁R, while weekly Cannabis use will cause downregulation of CB₁R. Thus, this approach will act to both reduce levels of the endocannabinoid signals and reduce the sensitivity of target cells to those signals. The net effect is predicted to be a more potent weight loss strategy than diet alone.