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. Author manuscript; available in PMC: 2019 Jan 21.
Published in final edited form as: J Invest Dermatol. 2011 Dec 15;132(3 Pt 2):811–819. doi: 10.1038/jid.2011.406

Figure 3. Integration of EGFR signaling circuitry:

Figure 3.

EGFR and other ERBB receptors dimerize after engagement with their ligands activating multiple signaling cascades through recruitment of adaptor and signaling proteins to the intracellular portion of the receptor. Phospholipase Cγ (PLC γ) activity triggers the activation or downmodulation of protein kinase C isoforms (PKCs) and increases intracellular calcium leading to the regulation and expression of proteins that control differentiation. Phosphoinositol 3’-OH kinase (PI3K) promotes survival responses through AKT activity. Activation of Ras regulates JNK1/2 and ERK1/2 MAPKs activity causing changes in gene transcription and mRNA stability. As a consequence, cell cycle progression and inflammatory responses are fine tuned by EGFR activity.