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Dosage, half-life and apparent therapeutic plasma concentrations of tricyclics and tetracyclics
| Drug | T½
(hours) [134–136] |
Dosage (mg/day) [137] |
Plasma concentration (ng/mL) [137] |
|---|---|---|---|
| Tertiary tricyclics | |||
| Amitriptyline | 13-36 | 100-300 | |
| Clomipramine | 19-40 | 100-250/300 | >150* |
| Imipramine | 8-21 | 100-300 | >200* |
| Secondary tricyclics | |||
| Desipramine | 15-24 | 75-300 | >125 |
| Nortriptyline | 26 | 50-150 | 50-150 |
Total plasma concentration + metabolite
