Table 3.
KEGG pathway enrichment for differentially expressed genes using the DAVID database
| Category | Term | FDR | Genes |
|---|---|---|---|
|
| |||
| Up | hsa04110:cell cycle | 2.16E–08 | E2F1, E2F2, CDK1, CDC6, PKMYT1, TTK, CDC20, PTTG1, SFN, CDC25C, CDC25A, CCNB1, CCNE1, CDC45, CCNB2, BUB1, BUB1B |
| hsa04080:neuroactive ligand–receptor interaction | 2.66E–04 | GABRD, CGA, GABRG2, GABRA2, GABRA3, GLRA2, LEP, GRM4, SSTR5, KISS1R, HTR1B, GABRR1, GRID2, NPFFR2, TAAR1, HTR1D, GLP1R | |
| hsa04115:p53 signaling pathway | 2.08E–02 | CCNB1, CDK1, CCNE1, CCNB2, SFN, GTSE1 | |
| hsa04060:cytokine–cytokine receptor interaction | 2.69E–02 | LEP, CCR8, CCL20, GDF5, EGF, BMP7, CCL7, IL11, CCL26 | |
| hsa04062:chemokine signaling pathway | 2.73E–02 | CCR8, GNGT1, CCL20, GNG13, GNG4, CCL7, CCL26 | |
| hsa00604:glycosphingolipid biosynthesis | 2.99E–02 | ST6GALNAC5, B4GALNT1 | |
| hsa04512:ECM–receptor interaction | 3.14E–02 | IBSP, COMP, COL2A1, COL11A1 | |
| hsa04350:TGF-beta signaling pathway | 3.33E–02 | COMP, GDF5, BMP7, PITX2 | |
| hsa03320:PPAR signaling pathway | 4.83E–02 | LPL, MMP1, FABP6 | |
| Down | hsa00830:retinol metabolism | 8.15E–10 | CYP3A4, CYP1A1, CYP2B6, CYP2C8, ADH1B, CYP26A1, ADH7, CYP1A2, CYP3A43, CYP2A13, CYP4A11, UGT2B17, CYP4A22, LRAT, ADH4, CYP2A6, CYP2A7, RDH16 |
| hsa00982:drug metabolism | 2.89E–05 | CYP3A4, CYP2B6, CYP2C8, ADH1B, ADH7, CYP1A2, CYP2E1, GSTM5, CYP3A43, CYP2A13, UGT2B17, ADH4, CYP2A6, CYP2A7 | |
| hsa04080:neuroactive ligand–receptor interaction | 1.79E–04 | GPR83, DRD1, GABRB3, DRD5, PTH1R, PRSS1, VIPR1, VIPR2, GCGR, GRIN2B, CNR2, GLP2R, GABRP, NPBWR1, GABRA5, NPY1R, NTSR1, NPY5R, GRIA1, CHRM2, GRM7, PTGDR, TBXA2R, AVPR1A, ADRA1A, CTSG, HTR2A | |
| hsa04060:cytokine–cytokine receptor interaction | 2.07E–04 | CXCR1, CNTFR, PF4, PF4V1, CCL24, CXCR5, CCL21, IFNG, XCR1, AMHR2, IL6, IL5, FLT3, TNFRSF13B, TNFRSF13C, IL26, CCL19, IL22, CCL17, CCR9, TSLP, CXCL14, PPBP, CD40LG, IL5RA, NGFR, IL2 | |
| hsa00980:metabolism of xenobiotics by CYP/CYP450 | 3.64E–04 | CYP3A43, CYP3A4, UGT2B17, CYP1A1, CYP2B6, ADH4, CYP2C8, ADH1B, ADH7, CYP2E1, CYP1A2, GSTM5 | |
| hsa00232:caffeine metabolism | 1.50E–03 | CYP2A13, NAT2, CYP2A6, CYP2A7, CYP1A2 | |
| hsa00983:drug metabolism | 2.10E–02 | CYP3A43, CYP3A4, CYP2A13, UGT2B17, NAT2, UPP2, CYP2A6, CYP2A7 | |
| hsa04340:Hedgehog signaling pathway | 2.00E–02 | WNT2, WNT1, WNT10A, WNT7B, WNT9A, HHIP, GAS1, WNT7A, BMP5 | |
Abbreviations: DAVID, Database for Annotation, Visualization and Integrated Discovery; FDR, false discovery rate; KEGG, Kyoto Encyclopedia of Genes and Genomes.