Table 4.

Topological features for each protein in PPI network

Gene	Degree	Gene	CC	Gene	BC	Gene	APL	Overlapped	Expression
GNGT1	87	IL6	0.3179	IL6	0.2515	IL6	3.1461	CCNB1	Up
GNG13	85	CHRM2	0.2989	UBE2C	0.1845	CHRM2	3.3455	CDK1	Up
GNG4	64	SH3GL2	0.2959	NGF	0.1695	SH3GL2	3.3792	GNG4	Up
CDK1	56	EGF	0.2947	TH	0.1586	EGF	3.3933	UBE2C	Up
CCNB1	52	ESR1	0.2890	GNGT1	0.1413	ESR1	3.4607	GNGT1	Up
CDC20	48	CCL20	0.2848	FOSB	0.1406	CCL20	3.5112	KIF4A	Up
BUB1	48	GNGT1	0.2846	MMP1	0.1388	GNGT1	3.5140	PF4	Down
CCNB2	47	GNG13	0.2823	CHRM2	0.1186	GNG13	3.5421	GNG13	Up
KIF2C	47	INS	0.2821	SH3GL2	0.1164	INS	3.5449
PMCH	45	UBE2C	0.2808	EGF	0.1106	UBE2C	3.5618
AURKB	44	PF4	0.2803	E2F1	0.1043	PF4	3.5674
CENPA	43	PTHLH	0.2786	ESR1	0.1013	PTHLH	3.5899
KIF20A	39	GNG4	0.2777	GNG13	0.0956	GNG4	3.6011
BUB1B	39	NGF	0.2766	INS	0.0904	NGF	3.6152
NCAPG	38	GNAO1	0.2728	KIF4A	0.0670	GNAO1	3.6657
CDCA8	38	KIF4A	0.2722	PTHLH	0.0669	KIF4A	3.6742
GCGR	37	PPBP	0.2713	CDK1	0.0637	PPBP	3.6854
NPSR1	37	GNA14	0.2709	ACAN	0.0632	GNA14	3.6910
BIRC5	37	LEP	0.2707	CCL20	0.0620	LEP	3.6938
TTK	37	TERT	0.2707	GNAO1	0.0593	TERT	3.6938
NDC80	37	GNAZ	0.2669	CAMK2B	0.0547	GNAZ	3.7472
DLGAP5	36	NGFR	0.2661	LPL	0.0444	NGFR	3.7584
UBE2C	35	SYT9	0.2655	CYP19A1	0.0430	SYT9	3.7669
CDC45	35	E2F1	0.2651	CCNB1	0.0417	E2F1	3.7725
PF4	34	HTR1B	0.2645	GNG4	0.0402	HTR1B	3.7809
KIF4A	34	CDK1	0.2639	CHRNA1	0.0394	CDK1	3.7893
PBK	34	PMCH	0.2639	PF4	0.0393	PMCH	3.7893
KIF23	34	HTR1D	0.2639	RHO	0.0370	HTR1D	3.7893
CXCR1	33	CCNB1	0.2625	NOS1	0.0353	CCNB1	3.8090
XCR1	33	CXCR1	0.2597	NGFR	0.0348	CXCR1	3.8511

Note: Top 30 genes were listed.

Abbreviations: APL, average path length; BC, betweenness centrality; CC, closeness centrality; PPI, protein–protein interaction.