. 2019 Jan 17;11:877–897. doi: 10.2147/CMAR.S186561

Table 5.

BinGO enrichment for genes in modules

Module	Description	FDR	Genes in test set

M1	Mitotic cell cycle	9.74E–37	CDCA5\|BUB1B\|CDCA8\|NCAPG\|TTK\|CENPA\|SKA1\|AUR KB\|CDC20\|CCNB2\|CCNB1\|PTTG1\|NUF2\|PBK\|NEK2\|BU B1\|CEP55\|DLGAP5\|UBE2C\|KIF23\|NDC80\|ANLN\|KIF18 A\|CDK1\|BIRC5\|KIF2C\|SPC24\|CDKN3\|SPC25
	Nuclear division	9.74E–37	CDCA5\|BUB1B\|CDCA8\|NCAPG\|SKA1\|AURKB\|CDC20\|C CNB2\|CCNB1\|PTTG1\|NUF2\|PBK\|NEK2\|BUB1\|CEP55\|D LGAP5\|UBE2C\|KIF23\|NDC80\|ANLN\|KIF18A\|CDK1\|BIRC 5\|KIF2C\|SPC24\|SPC25
	Mitosis	9.74E–37	CDCA5\|BUB1B\|CDCA8\|NCAPG\|SKA1\|AURKB\|CDC20\|C CNB2\|CCNB1\|PTTG1\|NUF2\|PBK\|NEK2\|BUB1\|CEP55\|D LGAP5\|UBE2C\|KIF23\|NDC80\|ANLN\|KIF18A\|CDK1\|BIRC 5\|KIF2C\|SPC24\|SPC25
	M phase of mitotic cell cycle	1.65E–36	CDCA5\|BUB1B\|CDCA8\|NCAPG\|SKA1\|AURKB\|CDC20\|C CNB2\|CCNB1\|PTTG1\|NUF2\|PBK\|NEK2\|BUB1\|CEP55\|D LGAP5\|UBE2C\|KIF23\|NDC80\|ANLN\|KIF18A\|CDK1\|BIRC 5\|KIF2C\|SPC24\|SPC25
	Organelle fission	1.65E–36	CDCA5\|BUB1B\|CDCA8\|NCAPG\|SKA1\|AURKB\|CDC20\|C CNB2\|CCNB1\|PTTG1\|NUF2\|PBK\|NEK2\|BUB1\|CEP55\|D LGAP5\|UBE2C\|KIF23\|NDC80\|ANLN\|KIF18A\|CDK1\|BIRC 5\|KIF2C\|SPC24\|SPC25
	M phase	2.75E–36	CDCA5\|BUB1B\|CDCA8\|NCAPG\|TTK\|SKA1\|AURKB\|CDC 20\|CCNB2\|CCNB1\|PTTG1\|NUF2\|PBK\|NEK2\|BUB1\|CEP 55\|DLGAP5\|UBE2C\|KIF23\|NDC80\|ANLN\|KIF18A\|CDK1 \|BIRC5\|KIF2C\|TRIP13\|SPC24\|SPC25
	Cell cycle phase	1.03E–35	CDCA5\|BUB1B\|CDCA8\|NCAPG\|TTK\|SKA1\|AURKB\|CDC 20\|CCNB2\|CCNB1\|PTTG1\|NUF2\|PBK\|NEK2\|BUB1\|CEP 55\|DLGAP5\|UBE2C\|KIF23\|NDC80\|ANLN\|KIF18A\|CDK1 \|BIRC5\|KIF2C\|TRIP13\|SPC24\|CDKN3\|SPC25
	Cell cycle process	5.27E–34	CDCA5\|BUB1B\|CDCA8\|NCAPG\|TTK\|CENPA\|SK A1\|AURKB\|CDC20\|CCNB2\|CCNB1\|PTTG1\|NUF 2\|PBK\|NEK2\|BUB1\|CEP55\|DLGAP5\|UBE2C\|KIF 23\|NDC80\|ANLN\|KIF18A\|CDK1\|BIRC5\|KIF2C\| TRIP13\|SPC24\|CDKN3\|SPC25
	Cell cycle	7.78E–34	CDCA5\|HJURP\|BUB1B\|CDCA8\|NCAPG\|TTK\|CENPA\|SK A1\|AURKB\|CDC20\|CCNB2\|CCNB1\|CDC45\|PTTG1\|NU F2\|PBK\|NEK2\|BUB1\|CEP55\|DLGAP5\|UBE2C\|KIF23\|ND C80\|ANLN\|KIF18A\|CDK1\|BIRC5\|KIF2C\|TRIP13\|SPC24\| CDKN3\|SPC25
	Cell division	8.53E–28	UBE2C\|CDCA5\|BUB1B\|CDCA8\|NCAPG\|KIF23\|SKA1\|A URKB\|NDC80\|CDC20\|CCNB2\|ANLN\|CCNB1\|PTTG1\| NUF2\|CDK1\|BIRC5\|NEK2\|KIF2C\|BUB1\|CEP55\|SPC24 \|SPC25
M2	G-protein-coupled receptor protein signaling pathway	4.81E–36	NPFFR2\|CHRM2\|PMCH\|CXCR5\|HTR2A\|ADRA1A\|GNGT 1\|GNA14\|GRM4\|CXCR1\|CNR2\|TBXA2R\|NPBWR1\|KISS 1R\|CCR9\|CCR8\|PROK2\|TAC3\|NTSR1\|P2RY12\|XCR1\|ED N2\|NPY5R\|GCGR\|HTR1D\|NPY1R\|HTR1B\|CCK\|AVPR1A\| SSTR5\|GNG13\|PPYR1\|PNOC
	Cell surface receptor-linked signaling pathway	8.03E–26	NPFFR2\|CHRM2\|PMCH\|CXCR5\|HTR2A\|ADRA1A\|GNGT 1\|GNA14\|GRM4\|CXCR1\|CNR2\|TBXA2R\|NPBWR1\|KISS 1R\|CCR9\|CCR8\|PROK2\|TAC3\|NTSR1\|P2RY12\|XCR1\|ED N2\|NPY5R\|EDN3\|GCGR\|HTR1D\|NPY1R\|HTR1B\|CCK\|A VPR1A\|SSTR5\|GNG13\|PPYR1\|PNOC\|PF4
	Signaling	6.64E–24	NPFFR2\|CHRM2\|PMCH\|CXCR5\|OXT\|HTR2A\|ADRA1A \|GNGT1\|GNA14\|GRM4\|CXCR1\|CNR2\|GRM7\|TBXA2R\| GNG4\|NPBWR1\|KISS1R\|CCR9\|CCR8\|PROK2\|TAC3\|CCL 19\|NTSR1\|P2RY12\|XCR1\|EDN2\|NPY5R\|CCL21\|EDN3\| CCL20\|GCGR\|HTR1D\|NPY1R\|HTR1B\|CCK\|AVPR1A\|SST R5\|GNG13\|APLN\|PPYR1\|PNOC\|GNRH2\|PF4
	Behavior	1.44E–23	PMCH\|OXT\|HTR2A\|GRM4\|CXCR1\|CNR2\|KISS1R\|CCR 9\|CCR8\|PROK2\|CCL19\|NTSR1\|XCR1\|EDN2\|NPY5R\|C CL21\|EDN3\|CCL20\|NPY1R\|HTR1B\|CCK\|AVPR1A\|PPBP \|PPYR1\|PF4
	Signaling pathway	3.33E–20	NPFFR2\|CHRM2\|PMCH\|CXCR5\|HTR2A\|ADRA1A\|GNGT 1\|GNA14\|GRM4\|CXCR1\|CNR2\|TBXA2R\|GNG4\|NPBW R1\|KISS1R\|CCR9\|CCR8\|PROK2\|TAC3\|NTSR1\|P2RY12\|X CR1\|EDN2\|NPY5R\|EDN3\|GCGR\|HTR1D\|NPY1R\|HTR1B \|CCK\|AVPR1A\|SSTR5\|GNG13\|PPYR1\|PNOC\|PF4
	Signaling process	2.04E–17	CHRM2\|PMCH\|OXT\|HTR2A\|ADRA1A\|GNGT1\|GNA14\| GRM4\|CNR2\|GRM7\|NPBWR1\|KISS1R\|PROK2\|CCL19\|N TSR1\|P2RY12\|XCR1\|EDN2\|NPY5R\|CCL21\|EDN3\|CCL2 0\|GCGR\|HTR1D\|NPY1R\|HTR1B\|CCK\|AVPR1A\|SSTR5\|G NG13\|APLN\|PNOC\|GNRH2\|PF4
	Signal transmission	2.04E–17	CHRM2\|PMCH\|OXT\|HTR2A\|ADRA1A\|GNGT1\|GNA14\| GRM4\|CNR2\|GRM7\|NPBWR1\|KISS1R\|PROK2\|CCL19\|N TSR1\|P2RY12\|XCR1\|EDN2\|NPY5R\|CCL21\|EDN3\|CCL2 0\|GCGR\|HTR1D\|NPY1R\|HTR1B\|CCK\|AVPR1A\|SSTR5\|G NG13\|APLN\|PNOC\|GNRH2\|PF4
	Signal transduction	1.43E–14	CHRM2\|PMCH\|OXT\|HTR2A\|ADRA1A\|GNGT1\|GNA14\| GRM4\|CNR2\|KISS1R\|PROK2\|CCL19\|P2RY12\|XCR1\|ED N2\|CCL21\|EDN3\|CCL20\|GCGR\|HTR1D\|NPY1R\|HTR1B\| CCK\|AVPR1A\|SSTR5\|GNG13\|APLN\|PNOC\|GNRH2\|PF4
	Response to stimulus	2.05E–12	NPFFR2\|CHRM2\|PMCH\|OXT\|HTR2A\|ADRA1A\|GNGT1\| GRM4\|CXCR1\|CNR2\|GRM7\|GNG4\|KISS1R\|CCR9\|CCR8 \|PROK2\|CCL19\|NTSR1\|P2RY12\|XCR1\|EDN2\|NPY5R\|C CL21\|EDN3\|CCL20\|GCGR\|HTR1D\|NPY1R\|HTR1B\|CCK\| AVPR1A\|PPBP\|GNG13\|APLN\|PPYR1\|PF4
	Response to chemical stimulus	2.96E–11	XCR1\|EDN2\|CCL21\|EDN3\|CCL20\|GCGR\|HTR1D\|NP Y1R\|HTR1B\|OXT\|CCK\|HTR2A\|AVPR1A\|PPBP\|ADRA1A \|GNG13\|CXCR1\|CNR2\|GNG4\|CCR9\|CCR8\|PROK2\|CC L19\|PF4
M3	Cyclic-nucleotide-mediated signaling	6.43E–09	GLP1R\|VIPR1\|GLP2R\|PTH1R\|DRD1\|PTHLH\|DRD5
	G-protein-coupled receptor protein signaling pathway	2.93E–08	VIPR1\|GPR15\|GLP2R\|PTH1R\|DRD1\|TAAR1\|PTHLH\|DR D5\|PTGDR
	Second messenger-mediated signaling	9.78E–08	GLP1R\|VIPR1\|GLP2R\|PTH1R\|DRD1\|PTHLH\|DRD5
	G-protein signaling, coupled to cyclic nucleotide second messenger	9.78E–08	VIPR1\|GLP2R\|PTH1R\|DRD1\|PTHLH\|DRD5
	Cell surface receptor-linked signaling pathway	2.27E–05	VIPR1\|GPR15\|GLP2R\|PTH1R\|DRD1\|TAAR1\|PTHLH\|DR D5\|PTGDR
	Signaling	3.01E–05	GLP1R\|VIPR1\|GPR15\|VIPR2\|GLP2R\|PTH1R\|DRD1\|CGA\|T AAR1\|PTHLH\|DRD5\|PTGDR
	Signaling pathway	5.37E–05	GLP1R\|VIPR1\|GPR15\|GLP2R\|PTH1R\|DRD1\|TAAR1\|PTH LH\|DRD5\|PTGDR
	Intracellular signal transduction	8.25E–05	GLP1R\|VIPR1\|GLP2R\|PTH1R\|DRD1\|PTHLH\|DRD5
	Cell–cell signaling	1.41E–04	VIPR1\|VIPR2\|DRD1\|CGA\|PTHLH\|DRD5
	Signal transduction	1.59E–04	GLP1R\|VIPR1\|VIPR2\|GLP2R\|PTH1R\|DRD1\|CGA\|PTHLH \|DRD5
	Signaling process	4.51E–04	GLP1R\|VIPR1\|VIPR2\|GLP2R\|PTH1R\|DRD1\|CGA\|PTHLH \|DRD5
	Cell communication	7.10E–04	VIPR1\|VIPR2\|DRD1\|CGA\|PTHLH\|DRD5
M4	Drug metabolic process	3.44E–16	CYP2A6\|CYP2C8\|CYP2B6\|CYP1A2\|CYP1A1\|CYP2E1\|C YP3A4
	Secondary metabolic process	4.89E–11	CYP26A1\|CYP2A6\|CYP1A2\|CYP1A1\|CYP2E1\|CYP3A4
	Oxidation reduction	2.91E–10	CYP26A1\|CYP2A6\|CYP2C8\|CYP2B6\|CYP4A11\|CYP1A2\|C YP1A1\|CYP2E1\|CYP3A4
	Steroid metabolic process	4.84E–10	CYP2A6\|CYP2B6\|CYP1A2\|CYP1A1\|UGT2B17\|CYP2E1\| CYP3A4
	Lipid metabolic process	1.79E–09	CYP26A1\|CYP2A6\|CYP2B6\|CYP4A11\|CYP1A2\|CYP1A1\| UGT2B17\|CYP2E1\|CYP3A4
	Response to drug	1.12E–07	CYP2A6\|CYP2C8\|CYP2B6\|CYP1A2\|CYP1A1\|CYP3A4
	Cellular catabolic process	2.17E–06	CYP26A1\|CYP2A6\|CYP2C8\|CYP2B6\|CYP1A2\|CYP1A1\| CYP3A4
	Small molecule metabolic process	3.78E–06	CYP26A1\|CYP2A6\|CYP2C8\|CYP2B6\|CYP4A11\|CYP1A2\| CYP1A1\|CYP3A4
	Cellular lipid metabolic process	6.87E–06	CYP26A1\|CYP4A11\|CYP1A2\|CYP1A1\|CYP2E1\|CYP3A4
	Catabolic process	9.30E–06	CYP26A1\|CYP2A6\|CYP2C8\|CYP2B6\|CYP1A2\|CYP1A1\| CYP3A4

Abbreviation: FDR, false discovery rate.