Table S1.
Clinicopathological parameters of 20 breast cancer and paired adjacent normal tissues analyzed in this study
| Parameters | Category | na | % |
|---|---|---|---|
| Age, years | Median 55.4 (range: 30–79) | ||
| <55.5 | 9 | 45.0 | |
| ≥55.5 | 11 | 55.0 | |
| Histological gradeb | |||
| G1–2 | 14 | 70.0 | |
| G3 | 6 | 30.0 | |
| Lymph node statusc | |||
| pN0 | 15 | 75.0 | |
| pN1–3 | 5 | 25.0 | |
| Distant metastasisc | |||
| pM0 | 18 | 90.0 | |
| pM1 | 2 | 10.0 | |
| TNM stagec | |||
| I–II | 17 | 85.0 | |
| III–IV | 3 | 15.0 | |
| Estrogen receptor status | |||
| Negative (IRSd 0–2) | 6 | 30.0 | |
| Positive (IRSd 3–12) | 14 | 70.0 | |
| Progesterone receptor status | |||
| Negative (IRSd 0–2) | 5 | 25.0 | |
| Positive (IRSd 3–12) | 15 | 75.0 | |
| HER2 statuse | |||
| Negative | 16 | 80.0 | |
| Positive | 4 | 20.0 |
Notes:
a
Female patients with primary, unilateral breast cancer were included.
b
According to Bloom and Richardson and modified by Elston and Ellis.1
c
According to UICC TNM classification in breast cancer.2
d
IRS according to Remmele and Stegner.3
e
Overexpression of the ERBB2 gene (Her-2/neu) was diagnosed to the threshold of the DAKO score system based on the IHC assay. Uncertain cases were additionally validated by the FISH assay.
Abbreviations: FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; IRS, immunoreactive score.