Figure 2.

Elevated numbers of B cells, plasma cells and T cells with activated mTOR complex 1 (mTORC1) in salivary glands of patients with pSS correlate with B cell hyperactivity. In the salivary glands of patients with pSS, increased numbers of B cells (A), plasma cells (B) and T cells (C) with activated mTORC1 were observed as compared with patients with nSS. (D) Numbers of T cells and plasma cells with activated mTORC1 (pS6+) as assessed by immunofluorescence correlate with IgG+ and IgM+ plasma cells. Medians are shown. Magnification: 400×. nSS, non-Sjögren’s sicca; pSS, primary Sjögren’s syndrome; pS6, phosphorylated S6.