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. 2019 Jan 11;5(1):e000808. doi: 10.1136/rmdopen-2018-000808

Figure 1.

Figure 1

Least squares mean (LSM) changes from baseline: (A) Patient Global Assessment of disease activity visual analogue scale (PtGA-VAS) (mm); (B) Pain-VAS (mm); (C) Patient Global Joint and Skin Assessment (PGJS-VAS) (mm) arthritis and psoriasis. *p≤0.05, **p<0.01, ***p<0.001 compared with placebo; results up to month 3 were based on a repeated-measures model including data up to month 3 for tofacitinib 5 mg twice daily, tofacitinib 10 mg twice daily and combined placebo group. Results after month 3 were based on a second repeated-measures model including data up to end of study for the four treatment sequences (tofacitinib 5 mg twice daily, tofacitinib 10 mg twice daily, placebo → tofacitinib 5 mg twice daily and placebo → tofacitinib 10 mg twice daily), reporting results after month 3 only. Missing values were not imputed. N is number of patients evaluable at each visit. BID, twice daily.