Figure 4.

Least squares mean (LSM) change from baseline in (A) Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Total score and (B) Ankylosing Spondylitis Quality of Life (ASQoL). *p≤0.05, **p<0.01, ***p<0.001 compared with placebo; results up to month 3 were based on a repeated-measures model including data up to month 3 for tofacitinib 5 mg twice daily, tofacitinib 10 mg twice daily and combined placebo group. Results after month 3 were based on a second repeated-measures model including data up to end of study for the four treatment sequences (tofacitinib 5 mg twice daily, tofacitinib 10 mg twice daily, placebo → tofacitinib 5 mg twice daily and placebo → tofacitinib 10 mg twice daily), reporting results after month 3 only. Missing values were not imputed. N is the number of patients evaluable at each visit. BID, twice daily.