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. Author manuscript; available in PMC: 2019 Jan 21.
Published in final edited form as: Methods Mol Biol. 2018;1655:29–41. doi: 10.1007/978-1-4939-7234-0_3

Figure 1.

Figure 1.

Outline of MIRA. This method enables analysis of the DNA methylation status in individual genes or across the entire genome. MIRA is based on the ability of the methyl-binding domain (MBD) proteins, the MBD2B/MBD3L1 complex, to specifically bind methylated CpG dinucleotides. Enriched DNA fractions can be analyzed on high-throughput microarray or NGS platforms.