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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Trends Microbiol. 2018 Jun 19;26(11):913–928. doi: 10.1016/j.tim.2018.05.012

Figure 4. Model of YF pathogenesis.

Figure 4.

Schematic model of the YF-induced pathogenesis process, starting from a mosquito bite and leading to hepatic apoptosis and cytokine storm. The pathogenesis process is divided into five distinct steps (noted from 1 to 5), and each tissue compartment into which YFV circulates is displayed in a distinctly colored box. Intense viral replication in the liver is thought to trigger a molecular chain reaction inducing severe cytokine imbalance and pro-inflammatory cytokine secretion, leading to severe vasculopathy and multi-organ dysfunction. DC, dendritic cells; pDCs, plasmacytoid dendritic cells.