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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Trends Microbiol. 2018 Jun 19;26(11):913–928. doi: 10.1016/j.tim.2018.05.012

Figure 5. Molecular and phenotypic differences between YFV-17D and YFV-Asibi infection.

Figure 5.

A. Location in the polyprotein of the amino acid differences between YFV-17D and YFV-Asibi. 32 amino-acid mutations between the two strains are shown, as well as three additional mutations (either M/M,I or S/S,P) due to Asibi clonal differences. B. Major differences between YFV-Asibi (red capsid) and YFV-17D (yellow capsid) infection directly or indirectly suggested by the literature and that could play a critical role in regulating YFV virulence or attenuation. Important biological questions related to each of the listed differences are highlighted. At the bottom of the figure are three more general outstanding questions that encompass our currently limited understanding of the viral and host determinants regulating YFV course of infection.