Skip to main content
. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: DNA Repair (Amst). 2018 Aug 23;71:82–86. doi: 10.1016/j.dnarep.2018.08.010

Figure 1. Mechanisms by which MMR selectively safeguards actively transcribed genes.

Figure 1.

Actively transcribed genes reside in euchromatin, which is not only replicated early, but also highly enriched for H3K36me3 and MutSα. As such, mispairs generated during DNA replication in actively transcribed genes are efficiently repaired by the H3K36me3-mediated MMR system. Similarly, the MMR system acts to directly or indirectly remove DNA lesions created during active transcription (A). In contrast, heterochromatin is replicated late and less enriched for H3K36me3 and MutSα, thus not all mismatches can be corrected in heterochromatin (B).