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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: J Neurochem. 2018 Dec 10;148(2):275–290. doi: 10.1111/jnc.14628

Figure 4. p38 is involved in chronic morphine-induced increases in presynaptic NMDAR activity in the spinal cord.

Figure 4.

A, original recordings and cumulative plots show the lack of effect of 50 μM AP5 on the frequency and amplitude of mEPSCs in a lamina II neuron from spinal cord slices pretreated with 5 μM SB203580 in morphine-treated rats. B, group data show a lack of effect of AP5 on the frequency and amplitude of mEPSCs in lamina II neurons in spinal cord slices pretreated with 5 μM SB203580 from morphine-treated rats (n = 10 neurons from 3 rats). C, representative current traces show the lack of effect of 50 μM AP5 on the amplitude of monosynaptic EPSCs of a lamina II neuron from spinal cord slices pretreated with SB203580 in a morphine-treated rat. D, original current traces show a lack of effect of AP5 on the PPR of evoked monosynaptic EPSCs in spinal cord slices pretreated with SB203580 in morphine-treated rats. E, summary data show the lack of effect of 50 μM AP5 on the amplitude (n = 10 neurons from 3 rats) and PPR (n = 9 neurons from 3 rats) of monosynaptic EPSCs in lamina II neurons from spinal cord slices pretreated with SB203580 in morphine-treated rats. Data are presented as means ± SEM.