SOD1(G93A) males demonstrate earlier muscle contractility reduction than SOD1(G93A) females. (A) Modeled twitch torque (normalized to body mass) (mN-m/g) outcomes of wildtype (WT) male mice (blue square, n=5), wildtype female mice (orange x, n=5), SOD1(G93A) male mice (red triangle, n=5) and SOD1 female mice (purple circle, n=5). (B) Modeled tetanic torque (normalized to body mass) (mN-m/g) outcomes in wildtype and SOD1(G93A) cohorts, organized by gender. Shaded regions depict 95% confidence interval.