Table 1.
Longitudinal outcome measurements in SOD1(G93A) and wildtype male mice.
| Age (PND) |
CMAP (mV) (±StDv) |
MUNE (±StDv) |
SMUP (µV) (±StDv) |
Normalized Twitch (mN-m/g) (±StDv) |
Normalized Tetanic (mN-m/g) (±StDv) |
|---|---|---|---|---|---|
| 35 | 45.0 (8.0) | 383 (109) | 250.4 (26.6) | 0.127 (0.02) | 0.59 (0.064) |
| 34.02 (8.3) | 323 (119) | 258.7 (73.2) | 0.093 (0.027) | 0.48 (0.12) | |
| 42 | 41.7 (4.7) | 376 (118) | 233.8 (73.3) | 0.096 (0.014) | 0.57 (0.089) |
| 30.46 (3.8) | 359 (127) | 184.2 (49.3) | 0.083 (0.018) | 0.46 (0.17) | |
| 49 | 46.8 (13.1) | 433 (158) | 208.2 (49.4) | 0.123 (0.018) | 0.57 (0.080) |
| 45.38 (5.0) | 367 (70) | 236.7 (46.2) | 0.079 (0.011) | 0.38 (0.054) | |
| 56 | 43.8 (6.9) | 390 (47) | 204.3 (34.2) | 0.142 (0.016) | 0.59 (0.06) |
| 34.28 (2.8) | 317 (78) | 201.2 (12.7) | 0.083 (0.016) | 0.34 (0.046) | |
| 63 | 30.0 (16.5) | 239 (106) | 211.8 (29.7) | 0.089 (0.043) | 0.40 (0.21) |
| 25.84 (13.9) | 200 (113) | 226.3 (56.1) | 0.057 (0.035) | 0.26 (0.15) | |
| 70 | 29.4 (9.1) | 293 (148) | 213.0 (69.9) | 0.102 (0.039) | 0.45 (0.21) |
| 23.9 (17.7) | 147 (132) | 318.1 (87.6) | 0.074 (0.029) | 0.38 (0.14) | |
| 77 | 31.5 (9.0) | 255 (118) | 230.4 (61.7) | 0.146 (0.011) | 0.59 (0.088) |
| 17.46 (15.1) | 105 (81) | 302.5 (68.0) | 0.057 (0.034) | 0.25 (0.14) | |
| 84 | 43.3 (11.4) | 481 (150) | 170.8 (51.4) | 0.138 (0.012) | 0.58 (0.093) |
| 14.2 (8.9) | 105 (87) | 240.2 (63.0) | 0.060 (0.032) | 0.21 (0.049) | |
| 91 | 42.3 (12.7) | 390 (99) | 199.9 (50.0) | 0.144 (0.011) | 0.59 (0.080) |
| 12.46 (7.3) | 102 (103) | 227.9 (107.8) | 0.046 (0.027) | 0.19 (0.12) | |
| 98 | 44.9 (3.6) | 397 (88) | 184.9 (45.8) | 0.123 (0.01) | 0.57 (0.036) |
| 11.06 (8.7) | 78 (73) | 291.4 (108.2) | 0.037 (0.014) | 0.16 (0.038) | |
| 105 | 49.9 (9.8) | 385 (86) | 249.0 (43.4) | 0.135 (0.019) | 0.60 (0.090) |
| 9.72 (10.4) | 77 (107) | 228.5 (55.6) | 0.031 (0.020) | 0.14 (0.081) | |
| 112 | 48.5 (9.3) | 409 (100) | 205.5 (75.2) | 0.118 (0.01) | 0.58 (0.029) |
| 9.95 (12.3) | 59 (64) | 293.0 (50.3) | 0.031 (0.015) | 0.17 (0.072) | |
| 119 | 42.1 (5.0) | 407 (145) | 200.1 (59.1) | 0.131 (0.001) | 0.60 (0.050) |
| 9.0 (8.4) | 45 (42) | 351.3 (100.0) | 0.037 (0.023) | 0.18 (0.074) |
SOD1(G93A) male mice (shaded, n=5); wildtype male mice (unshaded, n=5). Mean outcome measurements with standard deviation (StDv) in brackets. Twitch and tetanic outcome measurements were normalized to mouse body mass. Abbreviations: Compound muscle action potential (CMAP), motor unit number estimation (MUNE), single motor unit potential (SMUP), and post-natal day (PND).