Table 2.
Longitudinal outcome measurements in SOD1(G93A) and wildtype female mice.
| Age (PND) |
CMAP (mV) (±StDv) |
MUNE (±StDv) |
SMUP (µV) (±StDv) |
Normalized Twitch (mN-m/g) (±StDv) |
Normalized Tetanic (mN-m/g) (±StDv) |
|---|---|---|---|---|---|
| 35 | 50.6 (9.4) | 373 (75) | 249.3 (50.1) | 0.112 (0.005) | 0.53 (0.017) |
| 45.8 (11.8) | 387 (32) | 219.7 (45.1) | 0.109 (0.018) | 0.50 (0.081) | |
| 42 | 33.4 (16.3) | 262 (121) | 245.7 (70.5) | 0.097(0.036) | 0.41 (0.17) |
| 38.0 (21.4) | 275 (123) | 233.5 (54.7) | 0.079 (0.014) | 0.38 (0.12) | |
| 49 | 41.7 (16.6) | 287 (110) | 253.7 (55.7) | 0.113 (0.023) | 0.57 (0.10) |
| 34.1 (12.9) | 291 (173) | 211.9 (43.8) | 0.096 (0.031) | 0.42 (0.097) | |
| 56 | 37.3 (14.3) | 309 (108) | 211.2 (26.2) | 0.119 (0.020) | 0.52 (0.088) |
| 33.5 (11.0) | 236 (101) | 248.8 (52.0) | 0.097 (0.019) | 0.44 (0.074) | |
| 63 | 38.4 (8.2) | 291 (55) | 252.5 (46.5) | 0.119 (0.019) | 0.51 (0.095) |
| 31.9 (8.3) | 203 (76) | 257.7 (68.1) | 0.092 (0.030) | 0.40 (0.081) | |
| 70 | 40.1 (9.0) | 311 (117) | 240.4 (62.9) | 0.123 (0.036) | 0.62 (0.11) |
| 34.5 (13.8) | 219 (58) | 256.5 (86.3) | 0.102 (0.026) | 0.45 (0.12) | |
| 77 | 44.6 (6.8) | 277 (30) | 260.9 (61.2) | 0.127 (0.021) | 0.60 (0.068) |
| 33.3 (10.1) | 174 (77) | 333.3 (90.9) | 0.094 (0.013) | 0.40 (0.14) | |
| 84 | 41.5 (6.8) | 339 (141) | 231.5 (67.1) | 0.134 (0.014) | 0.62 (0.11) |
| 32.0 (8.9) | 196 (40) | 266.4 (52.6) | 0.106 (0.019) | 0.47 (0.11) | |
| 91 | 38.5 (9.5) | 407 (94) | 176.53 (28.3) | 0.135 (0.012) | 0.58 (0.062) |
| 31.2 (14.9) | 194 (90) | 301.5 (110.6) | 0.090 (0.014) | 0.43 (0.079) | |
| 98 | 42.4 (8.8) | 400 (91) | 172.5 (26.3) | 0.119 (0.016) | 0.55 (0.059) |
| 21.2 (9.5) | 156 (76) | 264.7 (73.3) | 0.081 (0.017) | 0.36 (0.086) | |
| 105 | 39.6 (5.8) | 391 (103) | 178.8 (37.3) | 0.119 (0.015) | 0.56 (0.11) |
| 21.7 (8.9) | 125 (23) | 291.6 (77.9) | 0.072 (0.034) | 0.28 (0.14) | |
| 112 | 45.5 (14.7) | 319 (35) | 218.9 (48.8) | 0.115 (0.010) | 0.55 (0.022) |
| 14.7 (4.0) | 83 (17) | 329.8 (118.2) | 0.062 (0.023) | 0.26 (0.061) | |
| 119 | 44.9 (14.3) | 347 (47) | 225.0 (30.4) | 0.134 (0.014) | 0.64 (0.043) |
| 13.8 (1.9) | 70 (14) | 328.0 (82.9) | 0.052 (0.022) | 0.23 (0.081) |
SOD1(G93A) female mice (shaded, n=5); wildtype female mice (unshaded, n=5). Mean outcome measurements with standard deviation (StDv) in brackets. Twitch and tetanic outcome measurements were normalized to mouse body mass. Abbreviations: Compound muscle action potential (CMAP), motor unit number estimation (MUNE), single motor unit potential (SMUP), and post-natal day (PND).