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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Trends Biochem Sci. 2018 Nov 13;44(2):125–140. doi: 10.1016/j.tibs.2018.10.005

Figure 2.

Figure 2.

The “metabolic” hypothesis for PXE. ABCC6 is located in the baso-lateral membrane of the hepatocyte where it secretes a compound X into the blood circulation. X is desributed throughout the body via the circulation and hypothesised to counteract the ectopic peripheral calcification that occurs in PXE patients with non-functioning ABCC6.