Skip to main content
. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: J Neurochem. 2018 Dec 21;148(2):252–274. doi: 10.1111/jnc.14627

Figure 10. α2δ−1 contributes to paclitaxel-induced pain hypersensitivity.

Figure 10.

(A–C). Time course of changes in the paw withdrawal thresholds tested with von Frey filaments (A), a heat stimulus (B), and a cold stimulus (C) in wild-type (WT) and α2δ−1 knockout (KO) mice treated with paclitaxel (n = 8 mice per group). BL, baseline before paclitaxel treatment. The 4 paclitaxel injections are indicated by the arrows. Data are expressed as means ± SEM. *P < 0.05, compared with respective baseline (BL) value before paclitaxel treatment (one-way ANOVA followed by Dunnett’s post hoc test). #P < 0.05 compared with the corresponding value at the same time point in WT mice (two-way ANOVA followed by Tukey’s post hoc test).