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RNA Pol II recognition of oxidative DNA lesions. a. Pol II recognition of 8-oxoguanine (8-oxoG) lesion. Canonical Watson-Crick pair is formed between 8-oxo dG and C (PDB ID: 3I4M), but 8-oxo dG adopts syn-form when pairing with adenine in the Pol II-active site (PDB ID: 3I4N). b. Pol II EC stalled at an 8,5′-cyclo-2′-deoxyadenosine (CydA) site (PDB IDs: 4X6A and 4X67). Color codes are the same as Figure 3.
