Table 1.

Definitions.

Facilitated diffusion	The ability of a DNA binding protein to sample multiple sites on DNA in a single binding encounter and is driven by thermal fluctuations and non- specific DNA binding. Synonyms: processive searching, DNA scanning, intramolecular transfer, and translocation.
Sliding	An intramolecular mode of facilitated diffusion where a protein diffuses along a single-DNA strand.
Hopping	An intramolecular mode of facilitated diffusion where a protein diffuses along DNA via microscopic dissociation/reassociation events, allowing sampling of both DNA strands.
Intersegmental transfer	An intermolecular mode of facilitated diffusion where a DNA binding protein transfers from one DNA segment to another via a jumping or a bridging mechanism.
Jumping	Similar to a hopping mechanism, but the site of reassociation is much farther from the site of dissociation or on a different DNA molecule.
Bridging	An intermolecular mode of facilitated diffusion where a protein with more than one DNA binding domain (or a dimeric form) transfers from one DNA segment to another via an intermediate where both DNAs are bound simultaneously.
Processivity	The ability of a DNA modifying enzyme to catalyze more than one reaction on a DNA molecule in a single binding encounter.