Skip to main content
. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: Mol Cell Endocrinol. 2018 Dec 4;482:1–10. doi: 10.1016/j.mce.2018.12.001

Fig. 4. Altered oxidative muscle fatty acid oxidation and reversal of insulin sensitivity by intralipid infusion in overnight fasted Bscl2−/− mice.

Fig. 4.

(A) CO2 and (B) acid-soluble metabolites (ASM) production after incubating 14C-palmitate with crude mitochondrial fraction isolated from SM of overnight fasted Bscl2+/+ and Bscl2−/− male mice (n=4/group). (C) A time line of procedures for saline (Sal)/intralipid infusion, basal 3-[3H] glucose infusion, hyperinsulinemic-euglycemic clamp and 2-[14C]DG injection in 13-15 weeks old male Bscl2−/− mice after an overnight (16 h) fast with blood glucose levels indicated at each stage. (D) Plasma NEFA before and during 6 h saline and intralipid infusion. (E) Basal and clamped insulin levels. (F) Glucose infusion rates (GIR) during the 120 min hyperinsulinemic-euglycemic clamp, (G) basal and clamped hepatic glucose production (HGP), (H) glucose disposal rate (GDR) and (H) glucose uptake of SM and GM after clamp. n=6 per genotype. *: p< 0.05 vs saline infused Bscl2−/− mice.