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CCL2 overexpression causes a conditioning lesion-like increase in neurite outgrowth by DRG neurons from mice that received 3 weeks earlier an injection of AAV5-CCL2. Neurite outgrowth was measured in explant (A-C) and in cell (D-F) cultures. In contrast, if CCL2 (200 ng/ml) was added directly to such cultures, no effect on neurite outgrowth was seen (G-L). *p<0.05, **p<0.001. Scale bar, 100 µm. From Niemi et al., 2016.
