Table 5. Paired comparison of remodeling mediators between UP and NP tissues within each endotype of CRSwNP.
| Parameters (pg/mg) | NE-NP (UP) | NE-CRSwNP (NP) | E-CRSwNP (UP) | E-CRSwNP (NP) |
|---|---|---|---|---|
| MMP-1 | 15.66 (8.747–34.57) | 175.5 (82.13–251.8) | 133.1 (110.3–152.8) | 315.1 (186.3–462.6)‡ |
| MMP-2 | 13,250 (9,540–15,300) | 13,360 (12,380–15,800) | 13,550 (10,840–15,830) | 12,300 (9,641–14,480) |
| MMP-3 | 432.8 (248.4–504.7) | 606.5 (522.3–860.4)* | 395 (363.3–562) | 852.1 (670.5–1,179)‡ |
| MMP-9 | 1,639 (985.8–5,451) | 8,857 (5,209–25,420)‡ | 761.3 (432.6–2,715) | 1,500 (1,166–9,699)* |
| TIMP-1 | 10,790 (6,341–11,630) | 6,868 (5,891–8,632) | 11,530 (10,960–12,160) | 9,872 (8,047–12,930) |
| M1T1 | 0.0132 (0.008751–0.01483) | 0.02511 (0.009179–0.03808) | 0.01183 (0.009449–0.01386) | 0.02692 (0.01977–0.04809)‡ |
| M2T1 | 1.308 (1.137–2.049) | 2.125 (1.632–2.237) | 1.2 (0.9085–1.367) | 1.115 (0.8052–1.766) |
| M3T1 | 0.04305 (0.03549–0.06414) | 0.08649 (0.06457–0.1419)† | 0.03433 (0.03048–0.04356) | 0.07475 (0.05614–0.158)‡ |
| M9T1 | 0.2287 (0.1061–0.5736) | 1.29 (0.6508–4.026)† | 0.0638 (0.03824–0.2365) | 0.1572 (0.0813–1.244)* |
Values in bold means significant differences compared with those of uncinate mucosa.
UP, uncinate process tissue; NP, nasal polyps; E, eosinophilic; NE, non-eosinophilic; CRSwNP, chronic rhinosinusitis with nasal polyps; MMP, matrix metalloproteinase; TIMP, tissue inhibitors of metalloproteinase; M1T1, ratio of MMP1 to TIMP1; M2T1, ratio of MMP2 to TIMP1; M3T1, ratio of MMP3 to TIMP1; M9T1, ratio of MMP1 to TIMP1.
*,†,‡The paired comparison of cytokine profiles between UP and NP: *P < 0.05, †P < 0.01, and ‡P < 0.001; n = 9 in NE-CRSwNP and n = 14 in E-CRSwNP).