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. 2018 Dec 28;9(102):37700–37714. doi: 10.18632/oncotarget.26491

Figure 5. Expression of CD74 in multiple myeloma cell lines and cytotoxicity of STRO-001 and catabolites.

Figure 5

(A) Multiple myeloma cell lines were evaluated for expression of CD74 using Alexa647-conjugated SP7219. Unstained cells were used as negative controls. (B) The ADC, STRO-001, was used to determine the EC50 and percent span of killing in these MM cell lines, while the unconjugated antibody SP7219 did not show any activity in these cell lines. (C) Cytotoxicities of catabolites SC401 and SC246 were compared with STRO-001 and reference maytansine SC347 in CD74-expressing (MM.1S) and non-expressing (OPM-2) cells.