Figure 1. ON108110 is a multi-kinase inhibitor.

(A) Structure of the ON108XXO benzo thiazolidinnes chemotype. (B) Structure of ON108110. (C) Calculation of IC₅₀ values against CDK4 and CDK6 and (D) CK2α1 and CK2α2 by ON108110. Recombinant proteins were incubated with the indicated concentrations of ON108110 and subjected to in vitro kinase assays as described in the materials and methods section. Values obtained were plotted as a function of log drug concentration. IC₅₀ values were determined by performing sigmoidal non-linear regression with a variable slope.