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. 2018 Dec 28;9(102):37753–37765. doi: 10.18632/oncotarget.26514

Figure 5. Modulation of cell cycle expression and induction of apoptosis in ON 108110-treated MCL and T-ALL cell lines.

Figure 5

(A) CEM and Granta-519 cells were treated with either DMSO or increasing concentrations of ON108110 (0.5-2.0μM) for 24 hours. Cell cycle analysis was performed using propidium iodide staining. (B) CEM, HBL-2, RS4-11 and Granta-519 cells were treated with either DMSO (vehicle) or increasing concentrations of ON108110 (0.5-2.0 μM) for 24 hours and stained with Annexin V/DAPI (C) Graphical representation of apoptosis induced as shown in B. (D) Granta-519 cells were treated with increasing concentrations of ON108110 for 24 hours. Caspase activation and viability were measured using the Caspase Glo 3/7 and Cell Titer Blue assay kits, respectively.