Table 3.
Top functions associated with Reproductive System Development and Function, identified by Ingenuity Pathway Analysis platform.
| Diseases or function annotation | p-value | Activation z-score | Genes and their direction of change | # Genes |
|---|---|---|---|---|
| Development of genital organ | 0.001 | 2.226 | Bmp7, C14orf39, Cyp11a1, Cyp19a1, Cyp26b1, Dnah9, Dnajc19, Dnd1, Fads2, Fkbp6, Fshr, Fst, H3f3a, Inhba, Inhbb, Mael, Mcmdc2, Mov10l1, Ngf, Nppc, Piwil2, Serpina5, Smc1b, Sohlh1, Sox9, Stra6, Tarbp2, Tbpl2, Tk1, Ubb, Wt1, Zmynd15 | 32 |
| Development of female reproductive tract | 0.001 | 2.113 | Cyp11a1, Cyp19A1, Fads2, Fshr, Fst, Inhba, Inhbb, Ngf, Nppc, Sohlh1, Stra6, Tbpl2, Ubb | 13 |
| Quantity of antral follicle | < 0.001 | 1.342 | Bmp7, Cyp19A1, Inhba, Ngf, Ngfr | 5 |
| Fertility | < 0.001 | 1.280 | Ctfr, Chdh, Cyp19a1, Dio3, Dppa3, Fads2, Fshr, H3f3a, H2-Ab1, Hsd17b1, Inhba, Inhbb, Khdc3l, Kmt2c, Pip5k1b, Rarg, Scara5, Serpina5, Spink13, Srd5a1, Stc1, Tk1, Wt1 | 23 |
| Quantity of gonad | < 0.001 | 1.173 | Bmp7, Cdkn2d, Cftr, Cyp19a1, Cyp26b1, Fads2, Fshr, Hsd17b1, Igf2, Il6r, Inhba, Inhbb, Itpa, Ngf, Wt1 | 16 |
| Quantity of ovarian follicle | < 0.001 | 1.122 | Bmp7, Cftr, Cyp19a1, Fads2, Fshr, Hsd17b1, Inhba, Inhbb, Ngf, Ngfr | 10 |
| Estrous cycle | 0.001 | 1 | C3, Cftr, Cyp19a1, Fads2, Fshr, Inhba, Ngf, Ngfr | 8 |
| Quantity of corpus luteum | < 0.001 | 0.896 | Cftr, Cyp19a1, Fshr, Hsd17b1, Inhba, Inhbb | 6 |
| Quantity of primary ovarian follicle | < 0.001 | −1 | Bmp7, Cyp19a1, Fshr, Ngf | 4 |
The activation z-score makes predictions by using information about the direction of gene regulation in the dataset. Positive z-score predicts an increase in the biological process or disease, while a negative z-score predicts a decrease (inhibition). −2 ≥ z-score ≥ 2 indicates a significant change. A red up arrow indicates an increase in the dataset; A green down arrow indicates a decrease in the dataset. p < 0.05 indicate a statistically significant, non-random association between a set of genes in the dataset and a related function.