Table 4.

Regulator Effects networks, identified by Ingenuity Pathway Analysis platform.

Regulators	Consistency score	Target genes in the dataset	Diseases and functions	Predicted relationship	Known regulator/disease relationship
FSH	3	$\text{↑}$Cyp11a1, $\text{↑}$Cyp19a1, $\text{↑}$Fshr, $\text{↑}$Fst, $\text{↑}$Inhba, $\text{↑}$Inhbb, $\text{↑}$Nppc, $\text{↑}$Tk1, $\text{↓}$Wt1	Development of female reproductive tract; Development of genital organ	Activation	2/2
$\text{↓}$ELF4	1.155	$\text{↓}$Cdkn1a, $\text{↓}$Cxcl2, $\text{↓}$Spp1	Cell movement of phagocytes	Inhibition	0/1
$\text{↑}$STAT1	−4.536	$\text{↓}$Angpt2, $\text{↓}$Apoe, $\text{↑}$C3, $\text{↓}$Cdkn1a, $\text{↓}$Cxcl2, $\text{↓}$Edn1, $\text{↓}$Serpina3	Cell movement of phagocytes	Inhibition	1/1
TNF	−6.791	$\text{↓}$Apoe, $\text{↓}$Bmper, $\text{↓}$Cdkn11a, $\text{↑}$Col1a1, $\text{↓}$Cyp26b1, $\text{↓}$Edn1, $\text{↑}$Frzb, $\text{↑}$Fst, $\text{↓}$Mndal, $\text{↑}$Igf2, $\text{↑}$Naglu, $\text{↓}$Ngfr, $\text{↓}$Sox9, $\text{↑}$Th, $\text{↑}$Thbs2, $\text{↑}$Tnfrsf1b, $\text{↑}$Vegfc	Development of sensory organ	Activation	1/1
IL1A	−7.506	$\text{↓}$Bcl3, $\text{↑}$Il18, $\text{↑}$Tac1	Inflammation of the limb	Activation	0/1
CSF2	−8.89	$\text{↑}$C3, $\text{↓}$Cd74, $\text{↓}$Cdkn1a, $\text{↓}$Cxcl2, $\text{↓}$Edn1, $\text{↑}$Inhba, $\text{↓}$Spp1, $\text{↑}$Tnfrsf1b	Cell movement of phagocytes	Inhibition	1/1
EPO	−11.023	$\text{↓}$Angpt2, $\text{↓}$Cdkn1a, $\text{↓}$Edn1, $\text{↑}$Il18, $\text{↓}$Spp1, $\text{↑}$Vegfc	Cell movement of phagocytes	Inhibition	1/1
LIF	−11.431	$\text{↓}$Cdkn1a, $\text{↓}$Cxcl2, $\text{↑}$Cyp19a1, $\text{↓}$Serpina3, $\text{↓}$Spp1, $\text{↑}$Tac1	Cell movement of phagocytes	Inhibition	0/1
IFNα	−11.839	$\text{↑}$C3, $\text{↓}$Cdkn11a, $\text{↓}$Cxcl2, $\text{↓}$Il17ra, $\text{↓}$Il6r, $\text{↑}$Mmp28	Cell movement of phagocytes	Inhibition	1/1
IFNγ	−14.500	$\text{↓}$Bcl3, $\text{↑}$Il18, $\text{↓}$Itgb2, $\text{↑}$Tac1	Inflammation of the limb	Activation	1/1

The networks are scaled by a consistency score, a measure of how causally consistent and densely connected a network is. A red up arrow indicates an increase in the dataset; A green down arrow indicates a decrease in the dataset.