Table 5.
RT2-PCR array gene expression in juvenile and adult GOAT KO mice.
| Gene symbol | Gene name NCBI | Juvenile ovary fold change (p-value) | Adult ovary fold change (p-value) |
|---|---|---|---|
| Grik3 | Glutamate receptor, ionotropic, kainate 3 | 2.7 (*0.01) | 1.30 (0.14) |
| Spocd1 | SPOC domain containing 1 | 2.6 (*0.01) | 0.74 (0.36) |
| Grem1 | Gremlin 1, DAN family BMP antagonist | 1 (0.97) | 1.67 (0.53) |
| Cyp19a1 | Cytochrome P450, family 19, subfamily a, polypeptide 1 | 0.6 (0.07) | 0.81 (0.76) |
| Inhba | Inhibin, beta A | 0.8 (0.24) | 0.9 (0.81) |
| Hspb7 | Heat shock protein family B (small) member 7 | 1.1 (0.63) | 2.85 (0.33) |
| Sohlh1 | Spermatogenesis and oogenesis specific basic helix-loop-helix 1 | 1.7 (*0.05) | 0.91 (0.66) |
| Drd4 | Dopamine receptor D4 | 0.6 (0.14) | 1.11 (0.73) |
| Leprotl1 | Leptin receptor overlapping transcript-like 1 | 0.8 (*0.02) | 0.73 (*0.04) |
| Dcdc2b | Doublecortin domain containing 2b | 1 (0.90) | 1.08 (0.68) |
| Cited4 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 | 0.8 (0.45) | 0.97 (0.93) |
| Rab3b | RAB3B, member RAS oncogene family | 1 (0.92) | 0.35 (*0.03) |
| Rab6b | RAB6B, member RAS oncogene family | 0.9 (0.63) | 2.02 (0.09) |
| Myh6 | Myosin, heavy polypeptide 6, cardiac muscle, alpha | 3.5 (* 0.01) | 0.35 (0.14) |
Gene expression changes in GOAT KO mice ovaries relative to WT controls.
*
p < 0.05.