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Representative Western blot and dose response densitometry analysis (A) show effects of IGF-I alone or IGF-I + Klotho at different concentrations on IGF-IR tyrosine phosphorylation in human placenta (n = 20), *p < 0.05 compared with IGF-I alone. Effect of Klotho in the activation induced by IGF-I in human placental explants (n = 20 placentas) on threonine AKT (B) and on threonine-tyrosine ERK42/44 (C). &p < 0.05 respect to the corresponding time with IGF-I alone.
