Table 4.
Prognostic performance of different lymph node staging systems before and after stratifying for NDLN.
| NDLN | ||||||
|---|---|---|---|---|---|---|
| Variables | ALL (n = 56, 747) | ≥ 12 (n = 16, 699) | < 12 (n = 40, 048) | |||
| C Index (95% CI) | AIC | C Index (95% CI) | AIC | C Index (95% CI) | AIC | |
| PLN (continuous) | 0.668 (0.663–0.672) | 290576.3 | 0.682 (0.677–0.688) | 186085.5 | 0.648 (0.641–0.655) | 86189.8 |
| LNR (continuous) | 0.673 (0.668–0.677) | 288763.7 | 0.684 (0.679–0.690) | 185052.7 | 0.651 (0.644–0.658) | 86050.7 |
| LODDS (continuous) | 0.682 (0.677–0.687) | 287860.5 | 0.691 (0.685–0.697) | 184338.2 | 0.652 (0.644–0.661) | 85970.4 |
| AJCC 8th N stage (3) | 0.666 (0.662–0.671) | 288397.0 | 0.681 (0.675–0.686) | 184632.6 | 0.647 (0.640–0.654) | 85899.4 |
| LNR, Rosenberg et al. (17) | 0.669 (0.664–0.673) | 287984.1 | 0.679 (0.673–0.684) | 184496.2 | 0.649 (0.642–0.656) | 85842.9 |
| LNR, Berger et al. (16) | 0.666 (0.662–0.670) | 288125.3 | 0.674 (0.669–0.679) | 184686.9 | 0.639 (0.632–0.646) | 85856.0 |
| LODDS, Wang et al. (26) | 0.659 (0.655–0.664) | 288619.9 | 0.665 (0.660–0.670) | 184888.2 | 0.629 (0.621–0.636) | 86265.7 |
| LODDS, Persiani et al. (24) | 0.659 (0.654–0.663) | 288994.6 | 0.673 (0.668–0.678) | 184899.7 | 0.616 (0.609–0.623) | 86388.1 |
NDLN, The number of dissected lymph nodes; AIC, Akaike's Information Criterion; C Index, Harrell's consistency Index; LNR, lymph node ratio; LODDS, log odds of positive lymph nodes; AJCC, American Joint Committee on Cancer; PLN, positive lymph node.