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. 2019 Jan 15;9:1561. doi: 10.3389/fphar.2018.01561

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Copyright © 2019 Blondeau, Béraud-Dufour, Lebrun, Hivelin and Coppola.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sortilin structural model. Sortilin complexed with NT structural model PDB 3F6K. The extracellular domain of sortilin, receptor for NT was crystallized and the tridimensional structure at 2A resolution was determined. Peptides binding (two sites) relates to the restricted space inside the tunnel of the b-propeller (Quistgaard et al., 2009, 2014). Sortilin is shown in gray and NT in red.