Figure 3.

Combined effect of paclitaxel and recombinant virus in breast cancer cells. MCF-7 and MDA-MB-231 cells were infected with rMV or rMV-BNiP3 in the presence of desired concentrations of paclitaxel. Cells infected either with rMV or rMV-BNiP3 or treated with drug alone were used as control for comparison. Infected cells were incubated at 37°C; CO₂ atmosphere and images of morphological changes induced were taken with microscope and compared with the respective controls. At 56 h post infection, cells were subjected to MTT assay to measure the percentage of cell viability. (A,C) Photomicrographs showing morphological changes induced following infection and drug treatment in MCF-7 and MDA-MB-231 cells, respectively. (B,D) Percentage of viability of infected MCF-7 and MDA-MB-231 cells treated with paclitaxel, respectively. ^**p ≤ 0.01; ^***p ≤ 0.001 and ^****p ≤ 0.0001.