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. 2019 Jan 15;8:676. doi: 10.3389/fonc.2018.00676

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Copyright © 2019 Lal and Rajala.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Caspase 3 activity in MDA-MB-231 cells infected with recombinant virus in combination with drugs. MDA-MB-231 cells were infected with rMV-BNiP3 followed by treatment with desired concentrations of paclitaxel or H2 compound. At 48 h post infection, caspase 3 activity, an indicator of apoptosis was measured. Caspase activity of TNBC cells treated with (A) paclitaxel and (B) H2 compound in combination with virus. Cells infected with rMV (p = 0.0395) and rMV-BNiP3 (p = 0.0002) in the presence of H2 compound showed significantly increased caspase 3 activity as compared to cells treated with H2 alone. ^*p ≤ 0.05; ^**p ≤ 0.01; ^***p ≤ 0.001 and ^****p ≤ 0.0001.