Table 3. Distribution of PDLIM4 polymorphisms and osteoporotic fractures risk.
| SNP | Case (n=540) | Control (n=540) | P value | Crude OR (95% CI) | P value | Adjusted OR (95% CI) |
|---|---|---|---|---|---|---|
| rs77584624 | ||||||
| TT | 415 (76.9%) | 424 (78.5%) | 1.00 (reference) | |||
| TG | 119 (22.0%) | 107 (19.8%) | 0.39 | 1.14 (0.84–1.54) | 0.44 | 1.07 (0.91–1.22) |
| GG | 6 (1.1%) | 9 (1.7%) | 0.47 | 0.68 (0.21–2.11) | 0.64 | 0.81 (0.35–1.37) |
| TG + GG | 125 (23.1%) | 116 (21.5%) | 0.51 | 1.10 (0.82–1.48) | 0.56 | 1.05 (0.90–1.20) |
| TT + TG | 534 (98.9%) | 531 (98.3%) | 1.00 (reference) | |||
| GG | 6 (1.1%) | 9 (1.7%) | 0.44 | 0.66 (0.21–2.05) | 0.60 | 0.80 (0.35–1.35) |
| T | 949 (87.9%) | 955 (88.4%) | 1.00 (reference) | |||
| G | 131 (12.1%) | 125 (11.6%) | 0.69 | 1.06 (0.81–1.38) | 0.74 | 1.03 (0.89–1.16) |
| rs78418541 | ||||||
| CC | 403 (74.6%) | 420 (77.8%) | 1.00 (reference) | |||
| CT | 114 (21.1%) | 109 (20.2%) | 0.57 | 1.09 (0.80–1.48) | 0.62 | 1.04 (0.89–1.21) |
| TT | 23 (4.3%) | 11 (2.0%) | 0.03 | 2.18 (1.00–4.83) | 0.05 | 1.38 (1.00–1.69) |
| CT + TT | 137 (25.4%) | 120 (22.2%) | 0.22 | 1.19 (0.89–1.59) | 0.25 | 1.09 (0.94–1.24) |
| CC + CT | 517 (95.7%) | 529 (98.0%) | 1.00 (reference) | |||
| TT | 23 (4.3%) | 11 (2.0%) | 0.04 | 2.14 (0.99–4.73) | 0.06 | 1.37 (0.99–1.67) |
| C | 920 (85.2%) | 949 (87.9%) | 1.00 (reference) | |||
| T | 160 (14.8%) | 131 (12.1%) | 0.07 | 1.26 (0.98–1.63) | 0.08 | 1.12 (0.99–1.25) |
| rs270611 | ||||||
| CC | 265 (49.1%) | 325 (60.2%) | 1.00 (reference) | |||
| CA | 175 (32.4%) | 194 (35.9%) | 0.45 | 1.11 (0.85–1.45) | 0.49 | 1.06 (0.91–1.22) |
| AA | 100 (18.5%) | 21 (3.9%) | <0.001 | 5.84 (3.47–9.92) | <0.001 | 1.84 (1.62–2.03) |
| CA + AA | 275 (50.9%) | 215 (39.8%) | <0.001 | 1.57 (1.22–2.01) | <0.001 | 1.25 (1.11–1.41) |
| CC + CA | 440 (81.5%) | 519 (96.1%) | 1.00 (reference) | |||
| AA | 100 (18.5%) | 21 (3.9%) | <0.001 | 5.62 (3.37–9.43) | <0.001 | 1.80 (1.60–1.96) |
| C | 705 (65.3%) | 844 (78.1%) | 1.00 (reference) | |||
| A | 375 (34.7%) | 236 (21.9%) | <0.001 | 1.90 (1.56–2.31) | <0.001 | 1.34 (1.24–1.46) |
| rs3900945 | ||||||
| TT | 235 (43.5%) | 247 (45.7%) | 1.00 (reference) | |||
| TC | 177 (32.8%) | 224 (41.5%) | 0.17 | 0.83 (0.63–1.09) | 0.19 | 0.91 (0.78–1.05) |
| CC | 128 (23.7%) | 69 (12.8%) | <0.001 | 1.95 (1.36–2.79) | <0.001 | 1.33 (1.15–1.52) |
| TC + CC | 305 (56.5%) | 293 (54.3%) | 0.46 | 1.09 (0.85–1.40) | 0.50 | 1.05 (0.93–1.19) |
| TT + TC | 412 (76.3%) | 471 (87.2%) | 1.00 (reference) | |||
| CC | 128 (23.7%) | 69 (12.8%) | <0.001 | 2.12 (1.52–2.96) | <0.001 | 1.39 (1.22–1.57) |
| T | 647 (59.9%) | 718 (66.5%) | 1.00 (reference) | |||
| C | 433 (40.1%) | 362 (33.5%) | <0.01 | 1.33 (1.11–1.59) | <0.01 | 1.45 (1.05–1.25) |
| rs366512 | ||||||
| CC | 368 (68.%) | 329 (60.9%) | 1.00 (reference) | |||
| CT | 163 (30.2%) | 186 (34.4%) | <0.01 | 0.32 (0.14–0.74) | 0.01 | 0.50 (0.26–085) |
| TT | 9 (1.7%) | 25 (4.6%) | 0.06 | 0.78 (0.60–1.02) | 0.07 | 0.89 (0.77–1.01) |
| CT + TT | 172 (31.9%) | 211 (39.1%) | 0.01 | 0.73 (0.56–0.94) | 0.02 | 0.85 (0.74–0.97) |
| CC + CT | 531 (98.3%) | 515 (95.4%) | 1.00 (reference) | |||
| TT | 9 (1.7%) | 25 (4.6%) | <0.01 | 0.35 (0.15–0.79) | 0.01 | 0.52 (0.27–0.88) |
| C | 899 (83.2%) | 844 (78.1%) | 1.00 (reference) | |||
| T | 181 (16.8%) | 236 (21.9%) | <0.01 | 0.72 (0.58–0.90) | <0.01 | 0.84 (0.74–0.95) |
| rs77486529 | ||||||
| AA | 421(78.0%) | 431(79.8%) | 1.00 (reference) | |||
| AG | 108 (20.0%) | 101 (18.7%) | 0.56 | 1.10 (0.80–1.50) | 0.61 | 1.05 (0.89–1.21) |
| GG | 11 (2.0%) | 8 (1.5%) | 0.47 | 1.41 (0.52–3.87) | 0.62 | 1.17 (0.68–1.61) |
| AG + GG | 119 (22.0%) | 109 (20.2%) | 0.46 | 1.12 (0.83–1.51) | 0.50 | 1.06 (0.91–1.22) |
| AA + AG | 529 (98.0%) | 532 (98.5%) | 1.00 (reference) | |||
| GG | 11 (2.0%) | 8 (1.5%) | 0.79 | 1.38 (0.51–3.79) | 0.64 | 1.16 (0.68–1.59) |
| A | 950 (88.0%) | 963 (89.2%) | 1.00 (reference) | |||
| G | 130 (12.0%) | 117 (10.8%) | 0.38 | 1.13 (0.86–1.48) | 0.42 | 1.06 (0.92–1.20) |
| rs71583465 | ||||||
| GG | 224 (41.5%) | 238 (44.1%) | 1.00 (reference) | |||
| GC | 234 (43.3%) | 228 (42.2%) | 0.51 | 1.09 (0.83–1.42) | 0.55 | 1.05 (0.91–1.20) |
| CC | 82 (15.2%) | 74 (13.7%) | 0.38 | 1.18 (0.81–1.72) | 0.43 | 1.08 (0.89–1.29) |
| GC + CC | 316 (58.5%) | 302 (55.9%) | 0.39 | 1.11 (0.87–1.43) | 0.42 | 1.06 (0.93–1.20) |
| GG + GC | 458 (84.8%) | 466 (86.3%) | 1.00 (reference) | |||
| CC | 82 (15.2%) | 74 (13.7%) | 0.59 | 1.13 (0.79–1.61) | 0.55 | 1.06 (0.89–1.24) |
| G | 682 (63.1%) | 704 (65.2%) | 1.00 (reference) | |||
| C | 398 (36.9%) | 376 (34.8%) | 0.32 | 1.09 (0.19–1.31) | 0.35 | 1.05 (0.96–1.14) |