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. 2019 Jan 15;9:3163. doi: 10.3389/fimmu.2018.03163

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Copyright © 2019 Smith, Burton, Kilembe, Lakhi, Karita, Price, Allen and Derdeyn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circos diagrams of VH and VL pairing networks at 7.5-months post-infection (time point 2). Germline genes were assigned to each VH and VL sequence from each gp120-reactive single B cell using NCBI IGBLAST and vquest analysis. Circos diagrams were utilized to illustrate the network of VH germline (shades of blue VH-1, yellow VH-2, shades of red VH-3, shades of green VH-4, purple VH-5, pink VH-6) with the paired VL κ (dark gray) or λ (light gray) germline from individuals infected by HIV-1 Subtype A (left column), Subtype C (center column), and Subtype A/C unique recombinants (right column). Band width is proportional to the number of paired sequences that contain those VH and VL pairs. The total number of paired sequences analyzed for each individual is shown.