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. 2019 Jan 15;5:186. doi: 10.3389/fcvm.2018.00186

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Copyright © 2019 Chapski, Rosa-Garrido, Hua, Alber and Vondriska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genes with promoter-TES loops tend to have organ-specific functions within the cell. (A) Illustration depicting a gene with promoter-TES interactions (left) and a gene with no promoter-TES interactions (right). (B) KEGG pathway analysis of the genes with significant (q < 0.01) Fit-Hi-C interactions between promoters and transcription end sites in the cardiac Hi-C data. Cardiac-related terms are highlighted in red. (C) KEGG pathway analysis for genes with significant promoter-TES Fit-Hi-C interactions in liver Hi-C data. Liver-related terms are highlighted in red. For panels (B,C), p-values are calculated using a hypergeometric test.