Table 1.

Top ten genera by network interconnectedness (Hubs) stratified by clinical state

	Rank	Genus	Mean (%)	Median (%)	Stdev	Prev. (%)	RA rank	Prev. rank	Metab.a
Baseline	1	Johnsonella	0.098	0.016	0.206	72.5	29	18	−
	2	Veillonella	3.455	1.460	4.994	95.0	6	5	−
	3	Propionibacterium	0.023	0.005	0.052	77.5	43	16	−
	4	Prevotella	12.537	6.257	15.089	100.0	2	1	−
	5	Pseudomonas	41.289	46.880	36.709	92.5	1	7	+
	6	Bifidobacterium	0.733	0.020	2.750	77.5	15	15	−
	7	Derxia	0.024	0.000	0.153	12.5	42	55	+
	8	Mogibacterium	0.111	0.002	0.333	55.0	28	32	−
	9	Aeromonas	0.000	0.000	0.001	6.3	94	70	+
	10	Streptococcus	9.705	5.769	11.204	98.8	3	3	+
Unwell	1	Mycoplasma	0.007	0.000	0.068	5.3	56	80	−
	2	Halomonas	0.001	0.000	0.003	18.1	94	51	+
	3	Enterococcus	1.715	0.006	5.806	57.9	11	25	+/−
	4	Solobacterium	0.499	0.035	1.812	72.5	16	10	−
	5	Helicobacter	0.005	0.000	0.033	8.8	61	62	+
	6	Pseudomonas	30.790	13.553	34.454	84.2	1	7	+
	7	Bifidobacterium	1.575	0.010	5.768	68.4	12	13	−
	8	Capnocytophaga	0.139	0.004	0.392	57.3	29	28	+/−
	9	Stenotrophomonas	9.389	0.096	18.196	87.7	4	6	+
	10	Porphyromonas	1.060	0.002	5.884	57.9	14	26	−
PE	1	Actinomyces	2.311	0.517	3.661	100.0	9	6	−
	2	Bergeyella	0.010	0.000	0.018	31.3	55	50	+
	3	Leptotrichia	0.039	0.004	0.072	75.0	37	25	−
	4	Selenomonas	0.015	0.000	0.027	31.3	49	49	−
	5	Treponema	0.004	0.000	0.011	18.8	63	61	+/−
	6	Dialister	0.046	0.002	0.127	50.0	36	39	−
	7	Propionibacterium	0.014	0.001	0.020	62.5	50	30	−
	8	Johnsonella	0.133	0.041	0.303	81.3	28	19	−
	9	Prevotella	9.927	7.086	12.885	100.0	3	2	−
	10	Solobacterium	0.077	0.020	0.137	87.5	31	15	−

Prev Prevalence, RA relative abdundance

^aMetab. Metabolism: + aerobic, − anaerobic +/− facultative anaerobic