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. 2019 Jan 21;9:244. doi: 10.1038/s41598-018-36338-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Signaling pathways involved in the rescue of arteriogenesis by ginger in plcg1^−/− embryos. (A) Pharmacological inhibition of Bmp (DMH-1) and Notch (LY411575) signaling pathways affect the rescue of dorsal aorta, analyzed by efnb2a in situ at 1 dpf. (B) Representative images of different treatment. White arrow indicates the dorsal aorta, underneath is the vein indicated by red arrow. Scale bars = 250 μm.