Fig. 5.

Circuit regulation of DRN 5-HT functional connectivity by fluoxetine. a Experiment schematic. b Second level analysis comparing fluoxetine (n = 9) to control (n = 4) condition indicate an increase in negative response amplitude in scan 2 and 3 relative to scan 1 in the prefrontal, cingulate and peri-hippocampal cortex, as well as amygdala and parts of the striatum, in the fluoxetine group. Colour scale = t-statistic (non-parametric test, p ≤ 0.05, cluster corrected), red-yellow colour bar indicating significance for fluoxetine < control comparison; see Supplementary Figure 15 for all brain slices. c COPEs comparing fluoxetine (yellow) and control (red) confirm an augmentation of the decreased response amplitudes in CBV within regions highlighted by the voxel-wise analysis (*p < 0.05, FDR corrected). Bound of box and centre line represent 25th, 50th, 75th percentiles, whiskers represent 1.5*inter-quartile range