Fig. 2. Cyfip1 haploinsufficiency leads to motor learning defects.

a Cyfip1^HET mice spent a similar amount of time sniffing control, non-social, odor (C) and social odor (S), whereas their Cyfip1^WT littermate spent more time sniffing the social odor (S) than the control one (C). b Cyfip1^HET mice and their Cyfip1^WT littermates spent a similar amount of time calling when exposed to females in estrus. c Cyfip1^HET mice and their Cyfip1^WT littermates buried a similar number of marbles. d The time Cyfip1^WT mice spent on an accelerating rotarod significantly increased over seven trials, whereas that of Cyfip1^HET did not. e Cyfip1^WT and Cyfip1^HET mice spent similar amounts of time on an accelerating rotarod on the first trial. f Cyfip1^WT and Cyfip1^HET mice’s velocity in the open field was similar. In (a) connected dots represent the same animal tested for the control (C) and the social (S) odors. All values in (b)–(d) are represented as mean ± SEM. In (a) and (d), statistical significance was tested by repeated measures ANOVA followed by Bonferroni Post-hoc test. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; and ****P ≤ 0.0001. In (b), (c), (e), and (f), statistical significance was tested by two-tailed Student’s t-test or one-tailed Mann–Whitney test