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. 2019 Jan 21;10:339. doi: 10.1038/s41467-018-08000-4

Table 1.

Body fat ratio-associated loci that have not previously been associated with an anthropometric trait

Chr Lead SNP Position (bp) MAF Most likely target gene Strongest associated trait β Disc P Disc β Repl P Repl P Meta Direction
chr1 rs4971091 155,143,768 0.377 KRTCAP2 α AFR - combined −0.024 8.23*10−8 −0.013 1.35*10−5 3.62*10−11 −−
chr1 rs180921974 155,268,131 0.023 THBS3 δ TFR - combined −0.102 1.05*10−12 −0.097 9.45*10−24 7.52*10−35 −−
chr2 rs62107261 422,144 0.047 FAM150B α AFR - combined −0.063 3.08*10−10 −0.078 3.67*10−30 1.80*10−38 −−
chr2 rs13011472 57,961,602 0.489 VRK2 α AFR - combined −0.024 4.81*10−8 −0.013 6.96*10−6 1.17*10−11 −−
chr2 rs148812496 198,540,352 0.497 RFTN α AFR - combined −0.03 2.41*10−8 −0.015 4.19*10−5 8.07*10−11 −−
chr3 rs4521268 49,137,904 0.333 WDR6 β TFR - combined −0.025 4.30*10−8 −0.021 5.00*10−12 1.46*10−18 −−
chr4 rs2241069 8,602,798 0.461 CPZ α TFR - females 0.033 1.56*10−8 0.019 7.86*10−7 3.97*10−13 ++
chr5 rs1317415 157,952,404 0.307 RP11-32D16.1 α LFR - females −0.034 6.11*10−8 −0.018 1.81*10−5 4.71*10−11 −−
chr5 rs34022431 176,677,563 0.026 NSD1 α AFR - combined 0.071 8.55*10−8 0.04 7.12*10−6 1.67*10−11 ++
chr7 rs56282717 150,657,095 0.243 KCNH2 α AFR - combined −0.027 5.00*10−8 −0.02 5.59*10−9 3.03*10−15 −−
chr8 rs2044387 8,907,950 0.425 ERI1 α AFR - females 0.035 1.14*10−8 0.024 1.03*10−9 1.69*10−16 ++
chr8 rs12546366 10,802,146 0.455 XKR6 α AFR - females 0.031 9.29*10−8 0.021 6.50*10−8 8.23*10−14 ++
chr9 rs10962638 16,846,111 0.142 BNC2 α TFR - combined −0.037 4.22*10−9 −0.014 3.90*10−4 4.50*10−10 −−
chr9 rs7039458 86,639,999 0.248 RMI1 β, δ TFR - females 0.038 2.07*10−8 0.028 3.32*10−10 7.20*10−17 ++
chr9 rs3780327 129,945,847 0.22 RALGPS1 α LFR - combined −0.031 1.95*10−9 −0.016 2.50*10−6 3.40*10−13 −−
chr10 rs34821335 72,433,203 0.273 ADAMTS14 β TFR - females 0.039 3.40*10−9 0.023 2.22*10−7 2.89*10−14 ++
chr10 rs11289753 96,026,184 0.432 PLCE1 α AFR - combined 0.03 2.41*10−12 0.021 1.60*10−12 1.22*10−22 ++
chr11 rs1138714 825,110 0.432 AP006621.1 α AFR - combined −0.024 5.47*10−8 −0.012 2.50*10−5 6.65*10−11 −−
chr11 rs71455793 65,715,204 0.046 TSGA10IP δ TFR - females −0.082 4.45*10−9 −0.039 1.85*10−5 8.29*10−12 −−
chr11 rs1789166 69,482,091 0.352 ORAOV1 α AFR - combined −0.027 1.85*10−9 −0.013 2.05*10−5 4.92*10−12 −−
chr12 rs11614785 50,880,422 0.341 LARP4 α TFR - females 0.04 1.37*10−10 0.026 2.93*10−10 1.15*10−18 ++
chr14 rs71420186 50,960,918 0.066 MAP4K5 α LFR - combined −0.05 8.25*10−9 −0.038 3.20*10−11 2.47*10−18 −−
chr15 rs35874463 67,457,698 0.059 SMAD3 δ TFR - females 0.069 3.58*10−8 0.064 1.44*10−14 3.10*10−21 ++
chr15 rs8026676 89,361,919 0.472 RP11-343B18.2 β TFR - females 0.034 7.24*10−9 0.02 2.71*10−7 6.37*10−14 ++
chr16 rs8057620 69,884,619 0.46 RP11-419C5.2 β AFR - females 0.035 2.27*10−9 0.024 4.40*10−10 1.79*10−17 ++
chr16 rs10584116 90,062,323 0.097 C16orf3 β TFR - females −0.052 8.99*10−8 −0.033 6.97*10−7 1.20*10−12 −−
chr17 rs2071167 42,287,519 0.235 ASB16 β LFR - combined −0.028 1.84*10−8 −0.023 1.05*10−6 1.58*10−10 −−
chr17 rs28394864 47,450,775 0.462 ZNF652 α TFR - females −0.036 8.89*10−10 −0.024 1.70*10−9 3.51*10−17 −−
chr19 rs62621197 8,670,147 0.029 ADAMTS10 δ TFR - females −0.105 2.17*10−9 −0.147 3.45*10−39 8.33*10−46 −−

Lead SNP denotes the strongest associated SNP at each locus. The Most likely target gene column denotes a gene related to the associated locus either by proximity to the lead SNP (α), LD (R2 > 0.8) with a lead eQTL SNP for the gene (β) or LD (R2 > 0.8) with a missense variant within the gene (δ). β—effect size estimate per allele. Meta analyses were performed with METAL53. Direction—summary of effect direction for the discovery and replication cohorts, with one + or − per cohort. The Disc and Repl subscripts denote effects and P-values in the discovery and replication cohorts, respectively. PMeta denotes the P-value for meta analyses