Table 1.
Modified HAI grading: inflammatory scores used in the present study
| A. Confluent necrosis | ||
| Absent | 0 | |
| Focal confluent necrosis | 1 | |
| Zone 3 necrosis in some areas | 2 | |
| Zone 3 necrosis in most areas | 3 | |
| Zone 3 necrosis + occasional portal‐central bridging | 4 | |
| Zone 3 necrosis + multiple portal‐central bridging | 5 | |
| Panacinar or multiacinar necrosis | 6 | |
| B. Focal (spotty) lytic necrosis, apoptosis and focal inflammation | ||
| Absent | 0 | |
| One focus or less per 10× objective | 1 | |
| Two to four foci per 10× objective | 2 | |
| Five to ten foci per 10× objective | 3 | |
| More than ten foci per 10× objective | 4 | |
HAI: Histological Activity Index; HAI grading scores = A + B; Possible maximum total scores = 10. Modified from the method described by Ishak et al. (1995).