Table 2.

Effects of Diet I and Diet II on hepatic neoplasm‐related lesions in NDEA‐induced hepatocarcinogenesis rats at 20th week

Parameters	ConD	ConD+NDEA	Diet I+NDEA	Diet II+NDEA
Mortality (%)	0/10 (0.0)	2/10 (20.0)*	0/10 (0.0)#	0/10 (0.0)#
Relative liver weighta	2.49 ± 0.20	3.59 ± 0.34**	3.23 ± 0.31*	2.86 ± 0.27##
Macroscopic lesions
Nodule incidence (%)	0/10 (0.0)	8/8 (100.0)**	3/10 (30.0)##	5/10 (50.0)#
Total number of nodules (n)	0	834**	3##	6##
Nodulemultiplicity (n)b	0	83.4 ± 61.9**	0.3 ± 0.5##	0.6 ± 0.7##
<1 mm	—	281 (42.1)	2 (66.7)	3 (60.0)
>1 mm <3 mm	—	238 (35.7)	1 (33.3)	2 (40.0)
>3 mm	—	148 (22.2)	0 (0.0)	0 (0.0)
Max nodule diameter(mm)	—	23.38 ± 14.52	1.00 ± 0.50##	1.40 ± 0.89##
Tumor volume (mm3)/rat	—	99.70 ± 90.51	0.10 ± 0.30##	6.80 ± 1.60##
Microscopic lesions
Low‐grade dysplasia incidence (%)	0/10 (0.0)	0/10 (0.0)	4/10 (40.0)#	2/10 (20.0)
Hepatic adenoma incidence (%)	0/10 (0.0)	1/10 (10.0)	0/10 (0.0)	0/10 (0.0)
HCC incidence (%)	0/10 (0.0)	9/10 (90.0)**	0/10 (0.0)##	0/10 (0.0)##
Liver metastases (%)	0/10 (0.0)	2/10 (20.0)	0/10 (0.0)	0/10 (0.0)

^aRelative liver weight = liver weight/body weight. ^bAverage number of nodules/nodules bearing liver. Data are means ± SD or n (%), n = 8–10. Comparisons: compared with ConD group, *p < 0.05; **p < 0.01; compared with ConD+NDEA group, ^# p < 0.05; ^## p < 0.01 (Fisher's exact test). ConD: normal control group; ConD+NDEA: model group, NDEA plus control diet‐treated group; Diet I+NDEA: NDEA plus Diet I‐treated group; Diet II+NDEA: NDEA plus Diet II‐treated group.