Table 1.

Models and iron metabolism markers studied.

Model	Sample	Marker studied	Studies	Workforce
G93A-SOD1 cells	SH-Y5Y human NeurobLastoma cells	DMT1 and TfRl	Hadzhieva et al., 2013	—
SOD1 G93A mouse	Spinal cord	Iron	Lee et al., 2015	4 SOD1 G93A/4 wild-type
SOD1 G37R mouse	Spinal cord	Iron DMT1, TfR1 ferroportin, ceruloplasmin	Jeong et al., 2009	4 SOD1 G37R/ 3 wild-type
SOD 1G93A rats	Serum	Hepcidin	Halon et al., 2014	15 SOD1 G93A/15 wild-type
ALS patients	Serum	Iron, transferrin, ferritin, TSC	Nadjar et al., 2012	629 ALS/297 controls
			Veyrat-Durebex et al., 2014	104 ALS/145 controls
			Goodall et al., 2008	60 ALS/ 44 controls
			Ikeda et al., 2012	92 ALS/ 92 controls
		Ferritin	Qureshi et al., 2008	30 ALS/ 30 controls
			Su et al., 2015	138 ALS/152 controls
		Pro-hepcidin	Mitchell et al., 2010	30 ALS/ 36 controls
	Cerebral cortex	Iron	Oba et al., 1993	15 ALS/49 controls
			Ignjatovic et al., 2013	46 ALS/ 26 controls

BCECs, blood capillary endothelial cells; BBB, blood–brain barrier; TfR1, receptor transferrin 1; DMT1, divalent metal ion transporter 1.