Table 1.

Parameters of release sensors.

Model No. /Parameter	1	2	3	4	5 young	5 mature	6	Unit
kon	1	0.9	0.9	3	1.21	1.15	0.044	×10−8 M−1s−1
koff	4000	9500	3000	3000	6500	7900	56	s−1
b, cooperativity factor	0.5	0.25	0.25	–	0.26	0.26	1
I+, basal fusion rate	2	–	–	–	–	–	–	×10−4 s−1
f, increase upon Ca2+ binding	31.3	–	–	–	–	–	–
γ, release rate	-	6000	5000	40000	6960	6960	1450	s−1
γ2, forward isomerization	–	–	–	30000	–	–	–	s−1
δ, backward isomerization	–	–	–	8000	–	–	–	s−1
kpriming	–	–	0.05	–	–	–	–	×10−8 M−1s−1
kunpriming	–	–	50	–	–	–	–	s−1
kfilling	–	–	8	–	–	–	–	s−1
kunfilling	–	–	12	–	–	–	–	s−1
kbasal	–	–	2	–	–	–	–	s−1