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. 2018 Nov 16;116(1):127–141. doi: 10.1016/j.bpj.2018.11.011

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© 2018 Biophysical Society.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Mouse ICM organoids express the PrE markers GATA4 and SOX17. Mouse tet::GATA6 ESCs were stimulated for 6 h with doxycycline (+ dox) to induce PrE differentiation. After the removal of dox, 200 cells formed ICM organoids and were cultured for 24 h or 48 h. (A) GATA4 and SOX17 expression was found on the edge of the ICM organoids 24 h after formation. NANOG expression was found within the ICM organoids. (B) GATA4 and SOX17 expression was maintained 48 h after ICM organoid formation. Microscope: Zeiss LSM880; objective: 40×/1.3 oil differential interference contrast; scale bars, 20 μm. To see this figure in color, go online.