Figure 2.

Exogenous CXCL4 infusion exacerbated LV dilation at Day 5 post-MI. (A) CXCL4 infusion increased CXCL4 levels by 64% in the Day 5 infarct. Unpaired t-test was used. (B) Infarct areas were comparable between saline and CXCL4 treated mice. Unpaired t-test was used. (C) LV volumes and dimensions in CXCL4 treated mice were higher than saline controls at Day 5 post-MI. Ejection fraction, fractional shortening, and LV anterior wall thickness in systole were similar between groups. n = 8–9/group. *P < 0.05 vs. saline and ^#P < 0.05 vs. respective Day 0. Two-way ANOVA was used. (D and E) Plasma CXCL4 levels in patients with MI positively correlated with end diastolic dimension (EDD) and negatively correlated with interventricular septal thickness in diastole (IVSd). n = 50. Pearson correlation analysis was used.